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The role of ferroptosis in LDL-DHA mediated tumor cell killing was further validated with the iron chelator, deferiprone (DFP), which was also able to block the cytotoxic activity of LDL-DHA ( Figure 2B )

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Among these populations, the PEN_3 and PEN_4 clusters had the highest expression of these early pancreatic markers, suggesting they were the most mature pancreatic progenitors at this stage

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Tissue inhibitors of metalloproteinases

In the heart, endothelial cells (EC) account for a large proportion of non-cardiomyocyte (CM) cells ( Functional cardiac endothelial impairment is most commonly assessed by invasive measurement of coronary flow reserve (CFR) or indirectly by peripheral flow-mediated vasodilation (FMD) upon hyperemic challenge, both of which assess the degree of imbalance between blood supply from the coronary arterial circulation and the metabolic demands of the myocardium (Shah et al., 2018)